pentobarbital will lessen the extent or outcome of darifenacin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Contraindicated (one)pentobarbital will decrease the extent or outcome of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Women of all ages